You didn't get the raise you'd expected for weeks. You were passed over for the promotion for which you'd gone into overdrive for six months to obtain. The new job you took that changed your career blew up in front of you.

In the 20 years since its launch, 40m people worldwide have taken the so-called wonder drug - but research revealed this week shows that Prozac, and similar antidepressants, are no more effective than a sugar pill.